Recent Publication: Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature

A recent publication in Scientific Reports by Brydges et al. titled "Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature" investigated whether indoles in the gut microbiome are associated with depression and anxiety. The study found that abundance of indoles is correlated with anxiety, but anxiety treatment was not related to the modulation of indoles in the gut. However, a peripheral gut microbiome-derived metabolite was associated with anxiety, indicating that disruption of the gut microbiome can contribute to neuropsychiatric disorders. 

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